A new center for interdisciplinary research in Neuroscience

Discern the infinitely small in order to grasp the complexity of the brain

The Institute for Interdisciplinary Neuroscience (IINS - UMR 5297) is a new research center that has officially opened its doors January 1st, 2011.
The IINS is part of the "Centre National de la Recherche Scientifique" & the "Université Bordeaux Segalen".

The IINS unites researchers with diverse areas of expertise, and creates a highly synergistic environment to promote:

> The development of innovative methods and investigation tools, especially those based on molecular biology, physiology, optics, chemistry, physics and computer science.

> The application of such tools to push the boundaries of the study of molecular events underlying the activity of the brain. This will include studying the morpho-dynamic and functional properties of the nervous system to understand the complexity of its molecular assemblies and functions at an integrated level.

> The development of the Bordeaux Imaging Center, a core facility of service, training and R & D in cellular imaging of international stature to permit the transfer to the scientific community and industry of the tools developed in IINS.


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Neuron - February 2014

Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels
ron 2014 Feb. 19;81(4):787-99. doi: 10.1016/j.neuron.2013.12.028

Carta M*, Lanore F*, Rebola N*, Szabo Z, Da Silva SV, Lourenço J, Verraes A, Nadler A, Schultz C, Blanchet C, Mulle C. 
(* equal contribution)

Voltage-gated potassium (Kv) channels are involved in action potential (AP) repolarization in excitable cells. Exogenous application of membrane-derived lipids, such as a
rachidonic acid (AA), regulates the gating of Kv channels. Whether membrane-derived lipids released under physiological conditions have an impact on neuronal coding through this mechanism is unknown. We show that AA released in an activity-dependent manner from postsynaptic hippocampal CA3 pyramidal cells acts as retrograde messenger, inducing a robust facilitation of mossy fiber (Mf) synaptic transmission over several minutes. AA acts by broadening presynaptic APs through the direct modulation of Kv channels. This form of short-term plasticity can be triggered when postsynaptic cell fires with physiologically relevant patterns and sets the threshold for the induction of the presynaptic form of long-term potentiation (LTP) at hippocampal Mf synapses. Hence, direct modulation of presynaptic Kv channels by activity-dependent release of lipids serves as a physiological mechanism for tuning synaptic transmission.

This paper has been commented in:

Retrograde signaling causes excitement. [Neuron. 2014]
Synaptic transmission: membrane lipids channel a message. [Nat Rev Neurosci. 2014]

+ Cf. Abstract in French (INSB)

This e-mail address is being protected from spambots. You need JavaScript enabled to view it : tel. +33 (0)5 57 57 40 86

PLOS Biology - March 2014

Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling
Published PLOS Biology: March 25, 2014 - DOI: 10.1371/journal.pbio.1001820

Rajesh Jayachandran*, Xiaolong Liu*, Somdeb BoseDasgupta*, Philipp Müller*, Chun-Lei Zhang, Despina Moshous, Vera Studer, Jacques Schneider, Christel Genoud, Catherine Fossoud, Frédéric Gambino, Malik Khelfaoui, Christian Müller, Deborah Bartholdi, Helene Rossez, Michael Stiess, Xander Houbaert, Rolf Jaussi, Daniel Frey, Richard A. Kammerer, Xavier Deupi, Jean-Pierre de Villartay, Andreas Lüthi,Yann Humeau, Jean Pieters
(* equal contribution)

article image

Memory and behavior depend on the proper transduction of signals in the brain, but the underlying molecular mechanisms remain largely unknown. Coronin 1 is
a member of a highly conserved family of proteins, and although its gene lies in a chromosome region associated with neurobehavioral dysfunction in mice and men, it has never been directly ascribed a specific function in the brain. Here we show that coronin 1 plays an important role in cognition and behavior by regulating the cyclic AMP (cAMP) signaling pathway. We find that when cell surface receptors are activated, coronin 1 stimulates cAMP production and activation of protein kinase A. Coronin 1 deficiency resulted in severe functional defects at excitatory synapses. Furthermore, in both mice and humans, deletion or mutation of coronin 1 causes severe neurobehavioral defects, including social deficits, increased aggression, and learning disabilities. Strikingly, treatment with a membrane-permeable analogue of cAMP restored synaptic plasticity and behavioral defects in mice lacking coronin 1.
Together this work not only shows a critical role for coronin 1 in neurobehavior but also defines a role for the coronin family in regulating the transmission of signals within cells.

This e-mail address is being protected from spambots. You need JavaScript enabled to view it , tel. 05 57 57 56 87 

Nature Neuroscience - March 2014

Spine neck plasticity regulates compartmentalization of synapses
Nature Neuroscience - March 2014

Jan Tønnesen, Gergely Katona, Balázs Rózsa, U Valentin Nägerl

The team of Valentin Nägerl at the University of Bordeaux has discovered a novel structural mechanism by which neurons can rapidly tune their synapses in response to stimulation. The study will appear online in the Journal Nature Neuroscience on March 20, 2014 (DOI 10.1038/nn.3682).

Dendritic spines have been proposed to transform synaptic signals through chemical and electrical compartmentalization. However, the quantitative contribution of spine morphology to synapse compartmentalization and its dynamic regulation are still poorly understood.
We used time-lapse superresolution STED imaging in combination with FRAP measurements, 2-photon glutamate uncaging, electrophysiology and simulations to investigate the dynamic link between nanoscale anatomy and compartmentalization in live spines of CA1 neurons in mouse brain slices.
We report a diversity of spine morphologies that argues against common categorization schemes, and establish a close link between compartmentalization and spine morphology, where spine neck width is the most critical morphological parameter. We demonstrate that spine necks are plastic structures that become wider and shorter after LTP. These morphological changes are predicted to lead to a substantial drop in spine head EPSP, while leaving overall biochemical compartmentalization preserved.


STED image of dendritic spines (left), scale bar 500 nm; concurrent FRAP experiment to measure diffusional coupling between spines and dendrite (right).

Valentin Nägerl
, tél. 05 57 57 10 97

Nanoscale Imaging of Synapses - March 2014

thumb_bookvalnagerl2014Nanoscale Imaging of Synapses

New Concepts and Opportunities

by This e-mail address is being protected from spambots. You need JavaScript enabled to view it , Antoine Triller (Eds.)

A recently published book by Springer Verlag, which has multiple contributions from IINS.

More details on Springer website, here

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